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Year Number of Results
1997 1
1998 2
1999 5
2000 7
2001 5
2002 8
2003 5
2004 11
2005 5
2006 5
2007 3
2009 6
2010 1
2011 5
2012 6
2013 4
2014 5
2015 4
2016 3
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2020 11
2021 4
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2023 16
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144 results

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Page 1
EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1.
Pan Y, Shu G, Fu L, Huang K, Zhou X, Gui C, Liu H, Jin X, Chen M, Li P, Cen J, Feng Z, Lu J, Chen Z, Li J, Xu Q, Wang Y, Liang H, Wang Z, Deng Q, Chen W, Luo J, Yang J, Zhang J, Wei J. Pan Y, et al. Adv Sci (Weinh). 2023 Apr;10(11):e2206792. doi: 10.1002/advs.202206792. Epub 2023 Feb 12. Adv Sci (Weinh). 2023. PMID: 36775874 Free PMC article.
Here, EH domain-binding protein 1-like protein 1 (EHBP1L1) is identified as a crucial mediator of IFN-gamma/JAK1/STAT1/PD-L1 signaling in RCC. EHBP1L1 is highly expressed in RCC, and high EHBP1L1 expression levels are correlated with poor prognosis and resistance to ICB. E …
Here, EH domain-binding protein 1-like protein 1 (EHBP1L1) is identified as a crucial mediator of IFN-gamma/JAK1/STAT1/PD-L1 signalin …
Expression and Purification of JAK1 and SOCS1 for Structural and Biochemical Studies.
Liau NPD, Babon JJ. Liau NPD, et al. Methods Mol Biol. 2018;1725:267-280. doi: 10.1007/978-1-4939-7568-6_21. Methods Mol Biol. 2018. PMID: 29322424
The most potent inhibitor of IFNgamma signaling is Suppressor of Cytokine Signaling 1 (SOCS1). SOCS1 negatively regulates IFNgamma signaling pathway (and other pathways) by directly inhibiting JAKs. Here, we describe a protocol for the recombinant production and pur …
The most potent inhibitor of IFNgamma signaling is Suppressor of Cytokine Signaling 1 (SOCS1). SOCS1 negatively regulates IFNg …
Insights into the expanding intestinal phenotypic spectrum of SOCS1 haploinsufficiency and therapeutic options.
Rodari MM, Cazals-Hatem D, Uzzan M, Martin Silva N, Khiat A, Ta MC, Lhermitte L, Touzart A, Hanein S, Rouillon C, Joly F, Elmorjani A, Steffann J, Cerf-Bensussan N, Parlato M, Charbit-Henrion F. Rodari MM, et al. J Clin Immunol. 2023 Aug;43(6):1403-1413. doi: 10.1007/s10875-023-01495-7. Epub 2023 May 9. J Clin Immunol. 2023. PMID: 37156989 Free PMC article.
One patient received anti-IL-12/IL-23 treatment while the other received the JAK1 inhibitor, ruxolitinib. Peripheral blood, intestinal tissues, and serum samples were analyzed before-and-after JAK1 inhibitor therapy using mass cytometry, histology, transcriptomic, a …
One patient received anti-IL-12/IL-23 treatment while the other received the JAK1 inhibitor, ruxolitinib. Peripheral blood, intestina …
MiR-155-5p-SOCS1/JAK1/STAT1 participates in hepatic lymphangiogenesis in liver fibrosis and cirrhosis by regulating M1 macrophage polarization.
Bi J, Liu J, Chen X, Shi N, Wu H, Tang H, Mao J. Bi J, et al. Hum Exp Toxicol. 2023 Jan-Dec;42:9603271221141695. doi: 10.1177/09603271221141695. Hum Exp Toxicol. 2023. PMID: 36651907 Free article.
The levels of miR-155-5p in the liver and peripheral blood gradually increased with aggravation of liver fibrosis. In vitro, SOCS1, a target of miR-155-5p, regulated macrophage polarization into the M1 phenotype through the JAK1/STAT1 pathway. CONCLUSION: MiR-155-5p …
The levels of miR-155-5p in the liver and peripheral blood gradually increased with aggravation of liver fibrosis. In vitro, SOCS1, a …
Influenza a virus antagonizes type I and type II interferon responses via SOCS1-dependent ubiquitination and degradation of JAK1.
Du Y, Yang F, Wang Q, Xu N, Xie Y, Chen S, Qin T, Peng D. Du Y, et al. Virol J. 2020 Jun 12;17(1):74. doi: 10.1186/s12985-020-01348-4. Virol J. 2020. PMID: 32532301 Free PMC article.
IAV infection upregulated the suppressor of cytokine signaling (SOCS) protein SOCS1, and SOCS1 mediated the ubiquitination and degradation of JAK1. CONCLUSION: Collectively, our findings suggest that IAV infection induces SOCS1 expression to promote …
IAV infection upregulated the suppressor of cytokine signaling (SOCS) protein SOCS1, and SOCS1 mediated the ubiquitination and …
Downregulated SOCS1 expression activates the JAK1/STAT1 pathway and promotes polarization of macrophages into M1 type.
Liang YB, Tang H, Chen ZB, Zeng LJ, Wu JG, Yang W, Li ZY, Ma ZF. Liang YB, et al. Mol Med Rep. 2017 Nov;16(5):6405-6411. doi: 10.3892/mmr.2017.7384. Epub 2017 Aug 29. Mol Med Rep. 2017. PMID: 28901399
In addition, western blotting indicated that JAK1, STAT1 and p-STAT1 expression was significantly enhanced. Fludarabine can inhibit phosphorylation of STAT1 and SOCS1 expression. ...The above results indicated that, when SOCS1 expression is downregulated, it …
In addition, western blotting indicated that JAK1, STAT1 and p-STAT1 expression was significantly enhanced. Fludarabine can inhibit p …
In cis "benign" SOCS1 variants linked to enhanced interferon signaling and autoimmunity.
Du Y, Brodeur KE, Hsu E, Chen L, Chen Q, Liu M, Cheng Q, Rosen S, Michniacki TF, Chou J, Lo MS, Platt CD, Lee PY. Du Y, et al. J Autoimmun. 2023 Oct 3;140:103119. doi: 10.1016/j.jaut.2023.103119. Online ahead of print. J Autoimmun. 2023. PMID: 37797401
Pro50Leu and p.Ala76Gly) in Suppressor of cytokine signaling 1 (SOCS1), flanking the kinase inhibitory domain that interacts with Janus kinases (JAK). Both variants were predicted to be benign by most in silico algorithms and neither alone affected the ability of SOCS1 …
Pro50Leu and p.Ala76Gly) in Suppressor of cytokine signaling 1 (SOCS1), flanking the kinase inhibitory domain that interacts with Jan …
The SOCS1 KIR and SH2 domain are both required for suppression of cytokine signaling in vivo.
Doggett K, Keating N, Dehkhoda F, Bidgood GM, Meza Guzman LG, Leong E, Kueh A, Nicola NA, Kershaw NJ, Babon JJ, Alexander WS, Nicholson SE. Doggett K, et al. Cytokine. 2023 May;165:156167. doi: 10.1016/j.cyto.2023.156167. Epub 2023 Mar 17. Cytokine. 2023. PMID: 36934508 Free article.
Mutation of the SOCS1-KIR or SH2 domain had no impact on the integrity of the SOCS box complex, however, mutation within the phosphotyrosine binding pocket of the SOCS1-SH2 domain specifically disrupted SOCS1 interaction with phosphorylated JAK1. In co …
Mutation of the SOCS1-KIR or SH2 domain had no impact on the integrity of the SOCS box complex, however, mutation within the phosphot …
Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization.
Zhu Y, Liu Y, Ma Y, Chen L, Huang H, Huang S, Zhang H, He Y, Tan C, He Y, Qiang L. Zhu Y, et al. Cell Rep. 2023 Nov 28;42(11):113430. doi: 10.1016/j.celrep.2023.113430. Epub 2023 Nov 14. Cell Rep. 2023. PMID: 37963021 Free article.
Our mechanistic exploration reveals that CEBPB drives the transcription of SOCS1/3 and SQSTM1/p62-mediated autophagy degrades CEBPB normally. Autophagy deficiency leads to CEBPB accumulation, and further promotes the expression of SOCS1/3. This process inhibits J …
Our mechanistic exploration reveals that CEBPB drives the transcription of SOCS1/3 and SQSTM1/p62-mediated autophagy degrades CEBPB n …
SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.
Diao Y, Wang X, Wu Z. Diao Y, et al. Mol Cell Biol. 2009 Sep;29(18):5084-93. doi: 10.1128/MCB.00267-09. Epub 2009 Jul 20. Mol Cell Biol. 2009. PMID: 19620279 Free PMC article.
However, it remained unclear how this is achieved mechanistically. We now show that SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by specifically inhibiting the LIF-induced JAK1/STAT1/STAT3 pathway via distinct targets; whereas SOCS1 and SOCS3 sele …
However, it remained unclear how this is achieved mechanistically. We now show that SOCS1, SOCS3, and PIAS1 promote myogenic differen …
144 results